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Home Defining the location of murine frizzy in relation to Fgfr2

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Identifier	Thesis 1848
Author	Paul, Emily L.
Title	Defining the location of murine frizzy in relation to Fgfr2
Publisher	Central Connecticut State University
Date	2006
Resource Type	Master's Thesis
Notes	Ahearn et al. (J. Heredity 93:210-213) have previously shown that the rat fuzzy and Charles River "hairless" mutations are defects in the same gene on rat Chromosome 1, and are likely orthologues of mouse frizzy (abbreviated fr) on mouse Chromosome 7. Furthermore, since these mutations appeared to map very near Fgfr2, a gene known to be expressed in hair follicles, it was suggested that all three variants might be due to defects in Fgfr2. Here, this hypothesis was tested by crossing fr/fr mice (from the standard inbred FS strain) with mice that carried a knock-out mutation in Fgfr2. Mice shown to be heterozygous for both mutations were phenotypically normal, indicating that fr is not an allele of Fgfr2. To map fr with respect to Fgfr2 (and other genes and markers on mouse Chromosome 7) we backcrossed these hybrid mice to the FS strain. Backcross progeny were typed for a variety of visible (pink-eye dilution, chinchilla, frizzy), behavioral (shaker-1), and molecular markers (Fgfr2, D7Mit41 and D7Mit332) to determine the order of and genetic distances between these linked loci. This analysis showed, for the first time, the correct order of the loci D7Mit41—fr—Fgfr2—D7Mit332. We anticipate that continued genetic mapping in the fr region will support a future attempt at positionally cloning the fr gene. With the cloned gene in hand, it will finally be possible to determine if mouse frizzy and rat fuzzy/hairless are really defects of the same gene.
Subject	Mice -- Genetics Mice -- Variation
Department	Department of Biomolecular Sciences
Advisor	King, Thomas R.
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	713734948
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