Log in
|
Help
|
English

English

Engish-Pirate

한국어

Search

Advanced Search

Find results with:

Add another field

Search by date

to

Searching collections:

CCSU Theses and Dissertations

Add or remove collections

Home A Comparison of the Incidence and Degree of Postoperative Myalgia and Muscle Fasciculations...

Reference URL

Share

Add tags

Comment

Rate

To link to this object, paste this link in email, IM or document

To embed this object, paste this HTML in website

A Comparison of the Incidence and Degree of Postoperative Myalgia and Muscle Fasciculations Associated with Dose and Duration of Succinylcholine Administration

View Description

Download

small (250x250 max)

medium (500x500 max)

large ( > 500x500)

Full Resolution

Print

you wish to report:

Your comment:

Your Name:

Submit

Cancel

...

Back to top

Powered by CONTENTdm®

Select the collections to add or remove from your search

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

Select All Collections

C

CCSU Student Publications

CCSU Theses and Dissertations

G

GLBTQ Archives

M

Modern Language Oral Histories

O

O'Neill Archives Oral Histories

P

Polish American Pamphlets

T

Treasures from the Special Collections

V

Veterans History Project

OK

Cancel

Identifier	Thesis 1956
Author	Overdiek, Ronda M.
Title	A Comparison of the Incidence and Degree of Postoperative Myalgia and Muscle Fasciculations Associated with Dose and Duration of Succinylcholine Administration
Publisher	Central Connecticut State University
Date	2008
Resource Type	Master's Thesis
Notes	Over fifty years after its introduction into clinical practice, succinylcholine is still the only depolarizing neuromuscular blocking agent used in this country today. It is highly favored in the clinical practice of anesthesia because of its rapid onset and short duration of action. However, succinylcholine's well known side effects, including postoperative myalgias (POM) and muscle fasciculations, continue to plague both clinicians and patients around the world. Patients who suffer from postoperative myalgias have reported that it can be severe enough to either prolong hospitalization or cause them to be bed bound for days after discharge. Muscle fasciculations have been implicated in causing adverse problems for patients, including hyperkalemia, increased creatinine kinase levels, and increased intracranial, intraocular, and intragastric pressures. For over 50 years, clinicians have employed various treatments in attempt to either abolish or at least decrease the incidence of both postoperative myalgias and muscle fasciculations. Although there are many pretreatments that are currently being used to prevent these adverse effects, there are very few studies that have compared the incidence and degree of postoperative myalgias and fasciculations with the dose and duration of succinylcholine administration. The aims of this study were to determine if, by altering the dose and/or duration of succinylcholine administration, the incidence and degree of muscle fasciculations and/or postoperative myalgias could be decreased. A total of 136 ASA I and II adult patients who received general anesthesia were enrolled in this prospective, double blinded, four arm randomized clinical trial. The study employed a 2 x 2 factorial design, with dose and administration factors, resulting in four study groups. The proportion of patients in each group with the outcome of interest was compared using the chi-square test and statistical calculations were based on an intention to treat analysis. There was a 34.2% lower rate in occurrence of muscle fasciculations with a slow succinylcholine administration time of 30 seconds compared to intravenous push (IVP). This was a highly statistically significant finding (p=0.0007). Altering the succinylcholine dosage (1.0 mg/kg vs. 0,.6 mg/kg) showed that muscle fasciculation occurrence was 5.5% less in patients who received 0.6 mg/kg, but this finding was not statistically significant (p=0.7506). There were no statistically significant findings with postoperative myalgias at either 24 or 48 hours when either the dose or duration of succinylcholine administration was altered. The incidence of muscle fasciculations can be significantly decreased with slow succinylcholine administration over 30 seconds. By decreasing the incidence of the fasciculations, clinicians may be able to reduce the adverse problems caused by fasciculations, including hyperkalemia, increased creatinine kinase levels, and increased intraocular, intracranial, and intragastric pressures.
Subject	Anesthetics -- Physiological effect Postoperative pain Myalgia
Department	Department of Biology
Advisor	Rollin, Ruth
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	713733910
Rating

Find results with:

Searching collections:

Home A Comparison of the Incidence and Degree of Postoperative Myalgia and Muscle Fasciculations...

A Comparison of the Incidence and Degree of Postoperative Myalgia and Muscle Fasciculations Associated with Dose and Duration of Succinylcholine Administration

Description

Tags

Comments