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The role of cell to cell interaction during parietal endoderm sheet migration
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The role of cell to cell interaction during parietal endoderm sheet migration
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Description
Identifier
Thesis
2180
Author
Kudra, Randal Scott
Title
The
role
of
cell
to
cell
interaction
during
parietal
endoderm
sheet
migration
Publisher
Central Connecticut State University
Date
2011
;
*
Resource Type
Master's Thesis
Notes
Cell
migration
is
an
essential
part
of
many
processes
including
embryonic
development
,
wound
healing
, and
unwanted
processes
like
metastasis
.
Further
study
of
cell
migration
is
needed
to
help
understand
these
processes
. A
cell
model
system
(F9
cells)
was
used
which
analogously
represented
early
mouse
embryo
development
to
investigate
cell
migration
during
early
development
.
Cell
migration
during
development
requires
cell-ECM
attachments
called
focal
adhesions
and
interactions
with
other
cells
.
Adherens
junctions
are the
best
known
cell-cell
adhesion
.
Previous
research
has
shown
that
adherens
junctions
are
present
in
F9-derived
parietal
endoderm
cells
.
Another
,
more
recently
discovered
,
type
of
cell-cell
attachment
is
with the
Nectin-Afadin
complex
. The
Nectin-Afadin
complex
has been
shown
to be
crucial
in
other
model
systems
of
cell
migration
and in the
formation
of
adherens
junctions
. The
research
presented
in this
thesis
will
look
at the
presence
of the
Nectin-Afadin
complex
in
F9-derived
parietal
endoderm
. The
research
will also
examine
the
molecular
function
of the
Nectin-Afadin
complex
and
examine
if this
function
is
consistent
with the
function
of the
Nectin-Afadin
complex
in
other
model
systems
.
Subject
Cell migration
Department
Department of Biomolecular Sciences
Advisor
Mulrooney, James P
Type
Text
Digital Format
application/pdf
Language
eng
OCLC number
804653116
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