Log in
|
Help
|
English

English

Engish-Pirate

한국어

Search

Advanced Search

Find results with:

Add another field

Search by date

to

Searching collections:

CCSU Theses and Dissertations

Add or remove collections

Home Effects of hyperoxia on the lungs of very low birth weight infants

Reference URL

Share

Add tags

Comment

Rate

To link to this object, paste this link in email, IM or document

To embed this object, paste this HTML in website

Effects of hyperoxia on the lungs of very low birth weight infants

View Description

Download

small (250x250 max)

medium (500x500 max)

large ( > 500x500)

Full Resolution

Print

you wish to report:

Your comment:

Your Name:

Submit

Cancel

...

Back to top

Powered by CONTENTdm®

Select the collections to add or remove from your search

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

Select All Collections

C

CCSU Student Publications

CCSU Theses and Dissertations

G

GLBTQ Archives

M

Modern Language Oral Histories

O

O'Neill Archives Oral Histories

P

Polish American Pamphlets

T

Treasures from the Special Collections

V

Veterans History Project

OK

Cancel

Identifier	Thesis 2126
Author	Guerrera, Margaret, 1961-
Title	Effects of hyperoxia on the lungs of very low birth weight infants
Publisher	Central Connecticut State University
Date	2010
Resource Type	Master's Thesis
Notes	Supplemental oxygen is one of the most prescribed interventions in the newborn intensive care unit (NICU). Hyperoxia is toxic to the lung tissue of preterm newborns particularly the very low birth weight infant and it has been implicated in the development of bronchopulmonary dysplasia (BPD) in these patients. The BDP observed in the NICU today (“new” BPD) has a different pathophysiology from the BPD that occurred during the era before the widespread use of surfactant replacement (“old” BPD). While the “new” BPD is milder than the “old” BPD, it continues to contribute to long term health problems in these infants. The work presented here supports the role of hyperoxia in the development of the “new” BPD. In various experimental models, hyperoxia was implicated in the dysregulation of the pulmonary vasculature and alveolar simplification through the disruption of important cell signaling pathways. Furthermore, the work illustrates that it is the exposure of the lung tissue itself to the oxygen that contributes to abnormal lung development and supports the conclusion that the lower the FIO2 breathed by the preterm VLBW infant the better it is for the health of the lung tissue. Caregivers in the NICU who are titrating oxygen according to a specified target SPO2 range may find that their patients go on to develop BPD in spite of their efforts. Until safe levels and appropriate outcomes are determined, a conservative approach for manipulating FIO2 is recommended with the goal of avoiding wide swings in oxygenation. Before the oxygen level is increased, a brief yet thorough bedside assessment that includes evaluating the infant’s respiratory and hemodynamic status in addition to monitoring the infant’s SPO2 is necessary. Furthermore, it is crucial that the caregiver be cognizant of how much and for how long oxygen is being administered to maintain a particular SPO2.
Subject	Birth weight, Low Premature infants--Physiology Oxygen therapy for premature infants--Complications
Department	Department of Biology
Advisor	Rollin, Ruth
Type	Text
Digital Format	Application/pdf
Language	eng
OCLC number	706480186
Rating

Find results with:

Searching collections:

Home Effects of hyperoxia on the lungs of very low birth weight infants

Effects of hyperoxia on the lungs of very low birth weight infants

Description

Tags

Comments