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Identification of the first differentiation event involved in human embryonic stem cell-derived neural lineage specification

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Identifier	Thesis 2080
Author	Banda, Erin
Title	Identification of the first differentiation event involved in human embryonic stem cell-derived neural lineage specification
Publisher	Central Connecticut State University
Date	2010
Resource Type	Master's Thesis
Notes	The ability of embryonic stem cells to give rise to all cells comprising the three germ layers – endoderm, mesoderm and ectoderm – highlights a powerful in vivo system for the study of early embryonic development. Human embryonic stem cell (hESC) derived- neural stem cells (NSCs) provide a means for understanding development of the mammalian nervous system as well as neurodegenerative diseases associated with atypical development and disease pathology of the nervous system. Here I demonstrate identification of the earliest neural stem cell gene expressed during in vitro NSC specification. In this study, Musashi1 (Msi1), a member of the Notch signaling pathway, has interestingly been identified as the earliest NSC marker expressed during monolayer differentiation of hESCs towards NSC fates. Notch signaling is well classified in its role for maintenance of NSC populations in vivo, as well as in vitro, but this early Msi1 expression suggests that Notch signaling may have a role in specification of early neurectodermal cells. The identification of the earliest NSC gene in vivo allows the possibility of the development of a hESC-derived NSC reporter line, capable of highlighting cells as they become allocated to the neural lineage. Additionally, purification of these early NSCs allows for the study and transplantation of purified NSC populations, without contaminating ESCs or other proliferative cell types capable of forming teratocarcinomas.
Subject	Cell differentiation Embryonic stem cells
Department	Department of Biomolecular Sciences
Advisor	Mulrooney, James P
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	694100878
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Identification of the first differentiation event involved in human embryonic stem cell-derived neural lineage specification

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