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Neuropsychological deficits in early versus late onset Alzheimer's Disease / Giselle Braganza

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Identifier	Thesis 1612
Author	Braganza, Giselle
Title	Neuropsychological deficits in early versus late onset Alzheimer's Disease / Giselle Braganza
Publisher	Central Connecticut State University
Date	2000
Resource Type	Master's Thesis
Notes	Alzheimer's Disease (AD) is a type of dementia characterized by a gradual and progressive decline of intellectual functioning, affecting 20-40% of the population over the age of eighty. It results in cognitive deficits such as impairments in memory, behavioral and emotional problems, and visuospatial skill deficits. Absolute diagnosis of AD is at autopsy; therefore, the diagnosis of AD prior to death is problematic, as there is no definitive diagnostic test. Several neuroimaging techniques have contributed to the detection of AD, but neuropsychological assessments have been the most beneficial in assessing cognitive deficits. It has been found that neuropsychological testing requires retesting in order to measure the progressive decline of cognitive functions due to AD. This method is extensive, time-consuming, and requires skilled professionals. It is therefore, appropriate to use brief neuropsychological testing. To date, the most common brief neuropsychological test is the Mini Mental State Examination (MMSE). The MMSE, however, is only accurate for patients with moderate to severe AD, but not for individuals in the early stages of AD. As well, the MMSE does not assess abstract reasoning, which may be an early indicator of AD. Early detection of AD is important for a number of reasons, primarily because it will allow the patient and their caregivers to prepare for the future. As well, early detection helps in the management and rehabilitation of AD, therefore, slowing the disease process. There are, however, only a handful of studies that have investigated the area of the early detection of AD. The goals of this study are two-fold. First, to investigate whether the revised version of the Quick Cognitive Screening Test (RQCST) which is a brief cognitive screening test, could be used to indicate the early onset of AD. This was determined by comparing the responses on the MMSE to the responses of the RQCST. Second, to determine whether abstract reasoning deteriorates early in the disease process and may indicate the early onset of AD. This is determined by comparing the Similarities subtest of the Weschler Adult Intelligence Scale-111-R (WAIS-III-R) and the abstract reasoning sections of the RQCST, both of which assess abstract reasoning. Three groups were assessed: those with Alzheimer's Disease, those with probable early Alzheimer's Disease and normals. All three groups were administered the (MMSE), the revised version of the Quick Cognitive Screening Test (RQCST), and the Similarities subtest of WAIS-III-R. The results of this study suggested statistically significant differences between the probable early Alzheimer's group, the normal group, and the Alzheimer's group on both the global scores and the subscales of the MMSE and the RQCST. It appeared that the Alzheimer's group performed poorly on all measures compared to the normal and probable early Alzheimer's group. The probable early Alzheimer's group and the normal group performed similarly on all of the measures. The Alzheimer's group performed poorly compared to the normal and probable early Alzheimer's group on sections of the RQCST that assessed abstract reasoning, and on the Similarities subtest of the WAIS-III-R. It was also observed that the sections of the RQCST that assess abstract reasoning correlated highly with the Similarities subtest. This suggests that the RQCST is a good measure of abstract reasoning.
Subject	Alzheimer's disease -- Diagnosis Neuropsychological tests
Department	Department of Psychology
Advisor	Mate-Kole, C. Charles
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	48105773
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Neuropsychological deficits in early versus late onset Alzheimer's Disease / Giselle Braganza

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