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Home Maternal insufficiency in rats homozygous for the shorn (SHN) mutation / Peter R. Berry

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Maternal insufficiency in rats homozygous for the shorn (SHN) mutation / Peter R. Berry

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Identifier	Thesis 1779
Author	Berry, Peter R., 1965-
Title	Maternal insufficiency in rats homozygous for the shorn (SHN) mutation / Peter R. Berry
Publisher	Central Connecticut State University
Date	2005
Resource Type	Master's Thesis
Notes	Rats that are hypotrichotic (lacking normal hair) due to the autosomal recessive shorn (shn) mutation showed a low survival rate in brother by sister matings in a breeding colony of SU/Csu rats. The majority of rats died before weaning. Subsequent breedings of female SU/Csu x Brown Norway F1 hybrids with normal hair (shn/+) to shn/shn SU/Csu male rats, and the reciprocal cross, indicated that the lack of survival was due to the mothers shnr/shn genotype rather than the pup's genotype. This observation suggested that, in addition to hairlessness, shd/shn may be responsible for "maternal insufficiency" in homozygous females. A "forced heterozygous" breeding plan was established with the line of rats exhibiting the shorn mutation, where heterozygous females (shn/+) with hair were crossed with homozygous (shd/shn) males to maintain the shorn line. For four generations, this produced a significantly larger litter size, as anticipated. By the fifth generation, however, heterozygous mothers also showed maternal insufficiency resulting in reduced litters. This genetic separation of the maternal insufficiency from the hypotrichotic phenotype indicated that these may be separate traits, and not a pleotropic effect of the same mutation. Concurrently, similar backcrosses of F1 hybrids of Brown Norway rats and Charles River hairless rats (another hypotrichotic line of rats) were set up to try to determine if maternal insufficiency was shorn-specific or else was simply a result of having no hair. Reciprocal crosses resulted in similar reduced litters where the mother had no hair. In summary, my results seem to indicate that maternal insufficiency in the shorn rats is a separate trait from hypotrichosis. This suggests that it should be possible, even if these two traits are linked, to select for a line with shn-generated hypotrichosis, but not the maternal insufficiency trait. By April 10,2005, backcrossing to wild-type RR rats produced one shn/shn mother which was tested and she reduced from around twelve down to zero pups before weaning. The results of the Charles River crosses appear to indicate the possibility of some involvement of maternal hypotrichosis in the litter reduction seen in this line. The litter reduction seen in Charles River hairless may, or may not have a cause distinct from that seen in Shorn rats.
Subject	Parental behavior in animals Rats -- Physiology Animal mutation
Department	Department of Biomolecular Sciences
Advisor	King, Thomas R.
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	61659233
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