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Home The tetraspanin, CD9, and its role in cell migration / Kellie Lynn Ahearn

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The tetraspanin, CD9, and its role in cell migration / Kellie Lynn Ahearn

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Identifier	Thesis 1777
Author	Ahearn, Kellie Lynn, 1978-
Title	The tetraspanin, CD9, and its role in cell migration / Kellie Lynn Ahearn
Publisher	Central Connecticut State University
Date	2004
Resource Type	Master's Thesis
Notes	The ability of cells to migrate is important for development, neurite formation, immune function, and other processes necessary for the life of an organism. However, the gaining of an inappropriate migratory function, as well as, uncontrolled proliferation and loss of tumor suppression, can lead to cancer. Migration is a multi-step process involving a variety of proteins and other cellular molecules. The basic steps in migration involve: a) filopodia extension and adherence to the extracellular matrix; b) movement of the cell body forward; and c) rear detachment and retraction. (Lauffenburger and Horwitz, 1996) Interactions between tetraspanins and integrins are important in cell adhesion and cell signaling processes in migration. CD9, a member of the tetraspanin family, plays multiple roles in migration, mediating processes like adhesion and filopodia extension though interactions with integrins and other migration associated molecules. One possible model indicates that once an integrin, like 1, adheres to the ECM, it then binds to CD9, which causes a conformational change in CD9. (Gutierrez-Lopez et al, 2003) CD9, then, acts as a "bridge" between the integrin and the cytoskeleton through interactions between other members of the tetraspanin web, or mediation of cytoskeleton-associated molecules, like focal adhesion kinase (FAK) and calcium. (Cook et al, 2002; Jennings et al, 1990; Anton et al, 1995) CD9 also plays an important role determining the metastatic nature of certain cancers. Though there are exceptions, CD9 is typically down regulated in invasive or metastatic cancers. Currently, it is hypothesized that down regulation of CD9 allows cancers to disassociate from the primary site of the cancer, and CD9 is re-expressed or another adhesion molecule is up regulated in order for the cancer to adhere to the new site. (Sauer et al, 2003) This thesis reviews current and "classic" journal literature focusing on CD9 interactions, particularly CD9's role in cell migration and cancer.
Subject	Cell migration
Department	Department of Biomolecular Sciences
Advisor	Mulrooney, James P
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	61522594
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