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Comparison of cyclic voltammetry and HPLC for the determination of phenol in over-the counter sore throat sprays / David A. Palmero

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Identifier	Thesis 1540
Author	Palmero, David A
Title	Comparison of cyclic voltammetry and HPLC for the determination of phenol in over-the counter sore throat sprays / David A. Palmero
Publisher	Central Connecticut State University
Date	1999
Resource Type	Master's Thesis
Notes	Although high-performance liquid chromatography (HPLCC) is the standard technique for the analysis of most pharmaceutical finished products and raw materials, voltammetric techniques, such as cyclic voltammetry, are rarely used for such analyses. For example, while the voltammetric analysis of phenol has been studied for many years, no such technique has been used in the routine analysis of phenol in pharmaceutical formulations such as sore throat sprays. In this study, the analysis of phenol in samples of cherry-flavored Chloraseptic® sore throat sprays by cyclic voltammetry was demonstrated. This method of analysis was shown to be just as accurate and dependable as HPLC, which is considered one of the standard methods in pharmaceutical analysis. In the cyclic voltammetry, the initial and final potentials were usually 200 mV and 1500 mV, respectively. The scan rate employed was 50 mV/sec. A 3.0 mm disk glassy carbon working electrode, a silver-silver chloride reference electrode and a platinum wire auxiliary electrode were used. The supporting electrolyte was 0.1 M HCI. Reverse-phase high-performance liquid chromatography (HPLC) with UV detection at 255 nm was also used to analyze the sore throat sprays. The column employed was a Bakerbond Narrow-Octadecyl, 4.6 x 250 mm, with 5 μm spherical particles. The mobile phase was 60% of 0.2 M phosphoric acid and 40% of methanol at a flow rate of 1.00 mL/min. The injection volumes were 10 μL. The % phenol results from cyclic voltammetry and HPLC were very similar for both lots of sore throat spray studied and in good agreement with the label claim of 1.4%. The % phenol results for cyclic voltammetry were all very similar regardless if the experiment was performed on different days, with different working electrodes or with different reference electrodes. This demonstrated the dependability of cyclic voltammetry. The precision was slightly better for HPLC than for cyclic voltammetry although this small difference is considered insignificant for most routine work.
Subject	High performance liquid chromatography Voltammetry Throat -- Diseases -- Treatment Phenol
Department	Department of Chemistry and Biochemistry
Advisor	Arena, James
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	42522485
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Comparison of cyclic voltammetry and HPLC for the determination of phenol in over-the counter sore throat sprays / David A. Palmero

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