Home
Browse All
Log in
|
Help
|
English
English
Engish-Pirate
한국어
Search
Advanced Search
Find results with:
error div
Add another field
Search by date
from
after
before
on
to
Searching collections:
CCSU Theses and Dissertations
Add or remove collections
Home
CCSU Theses & Dissertations
Effects of comfrey (Symphytum officinale) on rat liver morphology
Reference URL
Share
Add tags
Comment
Rate
To link to this object, paste this link in email, IM or document
To embed this object, paste this HTML in website
Effects of comfrey (Symphytum officinale) on rat liver morphology
View Description
Download
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
Print
1225.pdf
Description
Identifier
Thesis
2033
Author
Fursov, Margarita
Title
Effects
of
comfrey
(Symphytum
officinale)
on
rat
liver
morphology
Publisher
Central Connecticut State University
Date
2009
Resource Type
Master's Thesis
Notes
Comfrey
is
an
herb
traditionally
used
for
bone
healing
.
It
is
also
sold
as a
dietary
supplement
to
promote
respiratory
health
.
Comfrey
has been
banned
in
Canada
and
Germany
because
of its
link
to
liver
damage
or
failure
, but
remains
legal
in the
United
States
. The
high
concentrations
of
pyrrolizidine
compounds
in
comfrey
are
thought
to be
responsible
for
liver
toxicity
.
However
, there has been
little
investigation
of the
histological
changes
to
liver
or
other
organs
.
We
used
light
microscopy
to
determine
if there are
structural
changes
in
liver
,
kidney
and
lung
of
Sprague-Dawley
rats
caused
by
ingestion
of
comfrey
root
in
three
different
doses
for
two
weeks
.
Results
showed
a
difference
in
liver
section
between
control
and
comfrey
treated
animals
,
which
suggested
that the
cytoskeleton
of
treated
cells
was
altered
.
Human
liver
cells
in
culture
were
treated
with
comfrey
and then
stained
for
α-
tubulin
and
Phalloidin
to
visualize
microtubules
and
actin
respectively
. Also,
Hoechst
staining
was
performed
to
identify
nucleus
.
Results
showed
that in
some
cells
treatment
with
comfrey
caused
a
decrease
in
size
and
orientation
of
actin
filaments
,
whereas
in
other
cells
the
length
remained
the
same
,
however
they
lost
their
fibrilloactin
structure
and
appeared
to be
much
thinner
compared
to
control
cells
.
Results
suggested
that the
morphological
change
in
treated
hepatocytes
was
due
to the
change
of
cells
microfilaments
,
specifically
actin
.
Subject
Comfrey
Liver -- Morphology
Rats -- Physiology
Department
Department of Biomolecular Sciences
Advisor
Watson, Cheryl L
Type
Text
Digital Format
application/pdf
Language
eng
OCLC number
713735090
Rating
Tags
Add tags
for Effects of comfrey (Symphytum officinale) on rat liver morphology
View as list
|
View as tag cloud
|
report abuse
Comments
Post a Comment
for
Effects of comfrey (Symphytum officinale) on rat liver morphology
Your rating was saved.
you wish to report:
Your comment:
Your Name:
Submit
Cancel
...
Back to top
Select the collections to add or remove from your search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Select All Collections
C
CCSU Student Publications
CCSU Theses and Dissertations
G
GLBTQ Archives
M
Modern Language Oral Histories
O
O'Neill Archives Oral Histories
P
Polish American Pamphlets
T
Treasures from the Special Collections
V
Veterans History Project
500
You have selected:
1
OK
Cancel