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Home The Role of E-Cadherin in Parietal Endoderm Outgrowth Migration

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The Role of E-Cadherin in Parietal Endoderm Outgrowth Migration

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Identifier	Thesis 1885
Author	Damiano, Jeff
Title	The Role of E-Cadherin in Parietal Endoderm Outgrowth Migration
Publisher	Central Connecticut State University
Date	2007
Resource Type	Master's Thesis
Notes	Cell Migration is an integral part of normal biological development and biological processes, but also plays an important role in pathogenic processes including the progression of cancer towards metastasis. The mechanisms that regulate cell migration are not completely understood. Cells must exhibit a wide range of dynamics in order to become motile including establishing polarity and developing a leading edge to aid in the direction of movement. Cells must form focal adhesions, contacts with the extracellular matrix, in order to migrate. Recently, it has been shown that cell-cell adhesion may also have a role in the migration process. One of the major players responsible for cell-cell adhesion is E-cadherin, which forms adherens junctions containing several cytosolic adaptor proteins. It is these adherens junctions that form cell-cell junctions that enable cells to function as a "sheet-like" unit. This thesis looks at F9 derived parietal endoderm outgrowth as a model system to investigate the mechanisms that regulate migration of parietal endoderm in the establishment of extracellular embryonic tissues. Time-lapse photo imaging revealed that cells initially migrated away from the embryoid body in a sheet-like structure. Cells then went through a period where they were making transient cell-cell contacts. It was then observed that as the cells moved farther away from the embryoid body they appeared to be migrating as single cells. This led to the hypothesis that E-cadherin may be playing a role in cell migration. The data presented here suggest that E-cadherin is expressed in parietal endoderm and that it localizes to the cell surface. In addition the data suggest that adherens junctions are forming between parietal endoderm cells, based on the localization of key adherens junction components. The data also indicate that E-cadherin may play a role in the formation of the parietal yolk sac, and that the Rho/ROCK pathway may serve as a modulator of E-cadherin's function.
Subject	Cell migration
Department	Department of Biomolecular Sciences
Advisor	Mulrooney, James P
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	713735011
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