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Re-derivation of the B6.C-H2d/bBy inbred mouse strain to remove an unwanted spontaneously arising...
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Re-derivation of the B6.C-H2d/bBy inbred mouse strain to remove an unwanted spontaneously arising new barrier to histocompatibility
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Description
Identifier
Thesis
1730
Author
LaMonica, Kristi April
Title
Re-derivation
of the
B6.C-H2d/bBy
inbred
mouse
strain
to
remove
an
unwanted
spontaneously
arising
new
barrier
to
histocompatibility
Publisher
Central Connecticut State University
Date
2003
Resource Type
Master's Thesis
Notes
Minor
histocompatibility
(H)
antigens
are
typically
identified
as
barriers
to
transplantation
in
graft
exchange
experiments
between
major
histocompatibility
complex
(MHC)-matched
hosts
(Bailey
1975
;
Snell
and
Bunker
1960)
. This
approach
has
allowed
the
identification
and
genetic
mapping
of
more
than
50
distinct
minor
H
genes
in
inbred
strains
of
mice
(Perreault
et
al
.
1990
;
Simpson
1991
;
MGD
2003)
,
while
experimental
and
theoretical
methods
have
suggested
that
several
hundred
minor
H
genes
may
exist
in the
mouse
genome
(Bailey
and
Mobraaten
1969
;
Graff
and
Bailey
1973
;
Klein
1975
;
Graff
and
Brown
1978
;
Johnson
1981)
.
Minor
H
loci
encode
products
that are
eventually
presented
as
peptides
on the
cell
surface
in the
context
of
MHC
proteins
(Loveland
and
Fisher
Lindahl
1991
;
Loveland
et
al
.
1990
;
Rtzschke
et
al
.
1990
;
Speiser
et
al
.
1990
;
Wallny
and
Rammensee
1990)
. These
peptides
are
detected
as
minor
H
antigens
when
a
polymorphism
allows
them to be
perceived
as
foreign
to the
host
, and a
graft
rejection
occurs
.
Animals
of the
same
species
that
reject
grafts
due
to a
minor
H-
difference
are
said
to be
allogeneic
; those that
accept
exchanged
skin
grafts
are
called
isogeneic
.
Subject
Histocompatibility
X chromosome
Department
Department of Biological Sciences
Advisor
King, Thomas R.
Type
Text
Digital Format
application/pdf
Language
eng
OCLC number
713734099
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