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Home CCSU Theses & Dissertations Physiological characterization of the shorn (shn) mutation in rats

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Physiological characterization of the shorn (shn) mutation in rats

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Identifier	Thesis 1759
Author	Gist, Katja M.
Title	Physiological characterization of the shorn (shn) mutation in rats
Publisher	Central Connecticut State University
Date	2004
Resource Type	Master's Thesis
Notes	Rats lacking normal hairy coats were discovered several years ago among our colony of hairy albino rats. The trait was found to be controlled by a recessive allele of a gene we designated shorn (shn), which mapped to distal end of rat chromosome 7. Marker studies suggest that this mutation results from a chromosomal rearrangement that suppresses recombination in this region. During the crosses that were performed for the mapping, other unanticipated phenotypes became apparent that have been assessed physiologically. One of the main pleiotropic effects of this mutation is renal insufficiency. Homozygous mutants die before 14 months of age (mean age at death is 10.8 ± 2.1 months) and upon death, the kidneys appeared yellow and granular compared to the kidneys of the wild type rats. Physiological analysis of this mutation has involved studies of oxygen consumption and basal metabolic rate. Renal studies have focused on urinalysis studies and the assessment of renal function. The shn rats have a higher oxygen consumption and basal metabolic rate than their hairy counterparts due to an increased need to keep warm. The shn rats also have higher urine output and water consumption. Although the urine osmolality was variable in the rats, males tended to have more concentrated urine than the female rats. There were no apparent differences in urine osmolality between the shn and heterozygote (shn/+) hairy rats. Urinalysis studies including urine protein concentrations showed that males also contain much higher concentrations of protein in their urine, corresponding to the increased urine osmolality. Molecular studies have also been performed to assess renal function, through the use of Aquaporin protein identification and abundance. These studies may be beneficial in confining the mutation to a narrower area on Chromosome 7, and may provide further information on renal function and longevity.
Subject	Rats -- Physiology Animal mutation
Department	Department of Biological Sciences
Advisor	Rollin, Ruth
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	713734033
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Home CCSU Theses & Dissertations Physiological characterization of the shorn (shn) mutation in rats

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