Log in
|
Help
|
English

English

Engish-Pirate

한국어

Search

Advanced Search

Find results with:

Add another field

Search by date

to

Searching collections:

CCSU Theses and Dissertations

Add or remove collections

Home Mapping the Mouse frizzy Mutation on Chromosome 7 with a (BALB x FS )F1 x FS Backcross

Reference URL

Share

Add tags

Comment

Rate

To link to this object, paste this link in email, IM or document

To embed this object, paste this HTML in website

Mapping the Mouse frizzy Mutation on Chromosome 7 with a (BALB x FS )F1 x FS Backcross

View Description

Download

small (250x250 max)

medium (500x500 max)

large ( > 500x500)

Full Resolution

Print

you wish to report:

Your comment:

Your Name:

Submit

Cancel

...

Back to top

Powered by CONTENTdm®

Select the collections to add or remove from your search

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

Select All Collections

C

CCSU Student Publications

CCSU Theses and Dissertations

G

GLBTQ Archives

M

Modern Language Oral Histories

O

O'Neill Archives Oral Histories

P

Polish American Pamphlets

T

Treasures from the Special Collections

V

Veterans History Project

OK

Cancel

Identifier	Thesis 1913
Author	Haughton, Richard A. (Richard Alexander), 1981-
Title	Mapping the Mouse frizzy Mutation on Chromosome 7 with a (BALB x FS )F1 x FS Backcross
Publisher	Central Connecticut State University
Date	2007
Resource Type	Master's Thesis
Notes	The mouse frizzy (fr) mutation arose on a genetically mixed background and was first described by G.D. Snell of The Jackson Laboratory in 1951. Mice carrying this recessive mutation have curly vibrissae which can be observed as early as one to two days after birth and persists throughout the lifetime of the animal. The fr mutation is now maintained in an inbred mouse strain called FS. In the current work, we used polymerase-chain-reaction (PCR) -scorable marker analysis to screen a (BALB x FS)F1 x FS backcross panel of 373 animals for crossovers between D7Mit101 and D7Mit165—a 4.14 Mb region known (from previous work) to contain the fr locus. Here we report the identification of nine mice recombinant within this interval on Chromosome 7. These recombinants have allowed the localization of fr to a 2.69 Mb region distal to D7Csu5 and centromeric of D7Mit165, where only 74 genes are known to reside. This backcross panel may be used to further refine the location of fr, if sequence differences between the FS and BALB strains can be found in the critical region between D7Csu5 and D7Mit165, and if any of these sites have been separated from fr by the 6 crossovers we have screened. This refined map for the mouse fr mutation is expected to facilitate the identification of a small number of gene candidates, and the eventual positional cloning of this classic mouse mutation.
Subject	Chromosome abnormalities Animal mutation
Department	Department of Biomolecular Sciences
Advisor	King, Thomas R.
Type	Text
Digital Format	application/pdf
Language	eng
OCLC number	713733897
Rating

Find results with:

Searching collections:

Home Mapping the Mouse frizzy Mutation on Chromosome 7 with a (BALB x FS )F1 x FS Backcross

Mapping the Mouse frizzy Mutation on Chromosome 7 with a (BALB x FS )F1 x FS Backcross

Description

Tags

Comments