Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
Comfrey is an herb traditionally used for bone healing. It is also sold as a dietary supplement to promote respiratory health. Comfrey has been banned in Canada and Germany because of its link to liver damage or failure, but remains legal in the...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
In human hypertrophy and heart failure, death often occurs following an arrhythmia. Researchers are still looking for the underlying causes of these arrhythmias. It has been determined that ion channels control cardiac rhythm, and that...
Rats lacking normal hairy coats were discovered several years ago among our colony of hairy albino rats. The trait was found to be controlled by a recessive allele of a gene we designated shorn (shn), which mapped to distal end of rat chromosome 7....
Parental behavior in animals; Rats -- Physiology; Animal mutation
Rats that are hypotrichotic (lacking normal hair) due to the autosomal recessive
shorn (shn) mutation showed a low survival rate in brother by sister matings in a breeding
colony of SU/Csu rats. The majority of rats died before weaning. Subsequent...
Repeated exposure to addictive drugs causes unmistakable changes to occur on both a neuronal and a behavioral level. Certain circuits in the brain of an addict are forced to change and adapt to an environment of drug-induced chemical imbalance....
The pairing and recombination of homologous regions of the X and Y chromosomes, in an area known as the pseudoautosomal region (PAR), has been a phenomenon of interest since its discovery in 1934. Its presence seems to be limited to eutherian...
