The frizzy (fr) mutation in Mus musculus affects hair structure and formation. Early studies demonstrated that the gene responsible for frizzy assorts to mouse Chromosome 7 along with pink-eyed dilution (p), chinchilla (cch), and shaker-1 (sh-1). ...
Discovering RNA editing sites in model organisms provides an insight into their adaptations in addition to finding potential sites for gene expression regulation. In this study, we focused on the grin1b gene of Zebrafish due to its important...
The male sterility and histoincompatibility mutant, mshi, results from a recessive mutation that arose spontaneously in the BALB/cBy inbred mouse strain. Using a 402-member BALB/cBy-mshi/mshi (BALB/cBy-mshi C57BL/6J) F1 backcross panel, the...
Rats lacking normal hairy coats were discovered several years ago among our colony of hairy albino rats. The trait was found to be controlled by a recessive allele of a gene we designated shorn (shn), which mapped to distal end of rat chromosome 7....
The discovery of antibiotics was one of the greatest discoveries of the 21st 20th century (Van Kraaig, 1999 and Livermore, 2004). The current need for new antibiotics to fight bacterial pathogens that have become resistant is growing every day. ...
Considering the pleiotropic manifestations of the rare, inherited, bone marrow failure disease, Fanconi Anemia, afflicted patients must be evaluated and monitored by specialty physicians (such as dermatologists, opthamologists, gastroenterologists,...
Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
Cell migration is an essential part of many processes including embryonic development, wound healing, and unwanted processes like metastasis. Further study of cell migration is needed to help understand these processes. A cell model system (F9...
Tick-borne diseases have become a principal public health concern in the United States due to the tremendous increase in human contact with deer. This concern has been reflected in Connecticut as well in recent years. With changing demographic...
Ahearn et al. (J. Heredity 93:210-213) have previously shown that the rat fuzzy and Charles River "hairless" mutations are defects in the same gene on rat Chromosome 1, and are likely orthologues of mouse frizzy (abbreviated fr) on mouse Chromosome...
