Ahearn et al. (J. Heredity 93:210-213) have previously shown that the rat fuzzy and Charles River "hairless" mutations are defects in the same gene on rat Chromosome 1, and are likely orthologues of mouse frizzy (abbreviated fr) on mouse Chromosome...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
Frizzy (fr) is a spontaneous recessive mutation in mice characterized by curly vibrissae, a disheveled coat and short hair (Snell 1951). Previous linkage analysis located the mutant fr allele on Mus musculus Chromosome 7 (Falconer and Snell 1952)....
Infertility is a common problem, affecting approximately 10% of all couples attempting to conceive (Watson et al., 1998). Although numerous potential causes of human infertility exist, many cases are thought to have genetic etiologies, including...
Investigation of X-linked histocompatibility may offer an opportunity to find CD and HD minor H haplotype components which are widely separated on the X chromosome. The presence of the HX antigen is detected by placing parental strain grafts onto...
Minor histocompatibility (H) antigens are typically identified as barriers to transplantation in graft exchange experiments between major histocompatibility complex (MHC)-matched hosts (Bailey 1975; Snell and Bunker 1960). This approach has allowed...
Receptor-mediated endocytosis as a route of gene delivery shows promise as it is a natural cellular process and allows targeting of ligands to specific cells. A carrier system consisting of two important components: a targetable ligand,...
The autosomal recessive mshi mutation in BALB/cBy mice phenotypically causes reduced testis size and male sterility in homozygotes. The development of the mshi male generative organs, prior to three weeks of age, appears to lack observable...
The frizzy (fr) mutation in Mus musculus affects hair structure and formation. Early studies demonstrated that the gene responsible for frizzy assorts to mouse Chromosome 7 along with pink-eyed dilution (p), chinchilla (cch), and shaker-1 (sh-1). ...
The male sterility and histoincompatibility mutant, mshi, results from a recessive mutation that arose spontaneously in the BALB/cBy inbred mouse strain. Using a 402-member BALB/cBy-mshi/mshi (BALB/cBy-mshi C57BL/6J) F1 backcross panel, the...
The male sterility and histoincompatibility mutation (mshi) is an autosomal recessive mutation that produces apparently pleiotropic effects in mice. Mice homozygous for mshi manifest two distinct phenotypes. In both male and female mice, the...
The mouse frizzy (fr) mutation arose on a genetically mixed background and was first described by G.D. Snell of The Jackson Laboratory in 1951. Mice carrying this recessive mutation have curly vibrissae which can be observed as early as one to two...
The mouse frizzy (fr) mutation is a Mendelian recessive trait that affects hair structure and formation in mice. The mutation arose in a mouse of mixed origin at the Jackson Lab (Bar Harbor, ME) in 1951. Frizzy is known to be linked to other genes...
The recessive male sterility and histoincompatibility mutation (mshi) in the mouse generates pleiotropic effects on graft transplantation and male reproduction. Previous analysis of backcross mice using a large set of microsatellite markers has...
