Acetaminophen is extensively used as an analgesic and antipyretic agent, but at high doses it causes liver damage. The major metabolic pathways of acetaminophen are glucuronidation and sulfation. In addition to these pathways, acetaminophen...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
To date, the exact etiology of migraine remains unknown. However, the medical community has accepted Moskowitz’s trigeminovascular hypothesis as the most acceptable explanation. Moskowitz proposes that both the trigeminovascular system and the...
Physical fitness for men -- Measurement; Energy metabolism -- Measurement; Vitamin D
Physical performance is related to functional disabilities. Better interventions to improve function may be targeted if the determinants of physical performance are understood. We evaluated predictors of performance. The relationship of physical...
Sleep apnea syndrome is a disease that has become increasing more prevalent in the United States in the past fifty years. Because of the newness of this disease it can often be misdiagnosed or even completely missed in individuals. Sleep apnea...
Sports -- Physiological aspects; Women athletes -- Physiology; Menstrual cycle
There are several different physiological differences between males and females that can affect exercise performance. Particularly, women experience the menstrual cycle when variations of estrogen and progesterone occur every 23-38 days. This...
