Acetaminophen is extensively used as an analgesic and antipyretic agent, but at high doses it causes liver damage. The major metabolic pathways of acetaminophen are glucuronidation and sulfation. In addition to these pathways, acetaminophen...
Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
Comfrey is an herb traditionally used for bone healing. It is also sold as a dietary supplement to promote respiratory health. Comfrey has been banned in Canada and Germany because of its link to liver damage or failure, but remains legal in the...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
Postoperative nausea and vomiting (PONV) is a complication of surgery and anesthesia that has major implications in terms of delaying recovery and raising costs through an increase in time and resources necessary for treatment. In addition, PONV...
