Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
In human hypertrophy and heart failure, death often occurs following an arrhythmia. Researchers are still looking for the underlying causes of these arrhythmias. It has been determined that ion channels control cardiac rhythm, and that...
Infertility is a common problem, affecting approximately 10% of all couples attempting to conceive (Watson et al., 1998). Although numerous potential causes of human infertility exist, many cases are thought to have genetic etiologies, including...
One of the fundamental physical aspects of rocky intertidal habitats deals with wave exposure (as defined by fetch) and the impact it has on the quantity and diversity of intertidal organisms. This paper examined the rocky intertidal environment...
Rats lacking normal hairy coats were discovered several years ago among our colony of hairy albino rats. The trait was found to be controlled by a recessive allele of a gene we designated shorn (shn), which mapped to distal end of rat chromosome 7....
Parental behavior in animals; Rats -- Physiology; Animal mutation
Rats that are hypotrichotic (lacking normal hair) due to the autosomal recessive
shorn (shn) mutation showed a low survival rate in brother by sister matings in a breeding
colony of SU/Csu rats. The majority of rats died before weaning. Subsequent...
The mouse frizzy (fr) mutation arose on a genetically mixed background and was first described by G.D. Snell of The Jackson Laboratory in 1951. Mice carrying this recessive mutation have curly vibrissae which can be observed as early as one to two...
The purpose of this thesis is to explore images of imprisonment and escape within selected poems by Sylvia Plath. The causes of imprisonment are complex, and it is my intention to relate imprisoning features in Plath's poetry to Plath's family,...
The tick has ability to transmit a greater variety of infectious agents to humans and other animal species than any other blood-feeding arthropod. Feeding over a period of days induces specific host hemostatic, inflammatory, and immune responses....
This study sought to determine if recreational swimming had an impact on the quality of water and the health of plant and animal species in the Scovill Reservoir in Wolcott, Connecticut. Specifically, it was designed to find out the extent to which...
