Fluorescence in situ hybridization; Lungs -- Cancer
This study examines the relationship ovserved between the chromosomal
abnormalities detected by FISH and available clinical data on cancer type on
forty lung cancer specimens. An attempt to derive correlation between subtype
of lung cancer and type...
Tick-borne diseases have become a principal public health concern in the United States due to the tremendous increase in human contact with deer. This concern has been reflected in Connecticut as well in recent years. With changing demographic...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
Myogenesis is an important process that occurs during the developmental stages of an embryo. Stem cells learn of their fate during this course if they will become muscle cells and from there, differentiation within those muscle cells will take...
Cyclin D1 is the major regulator of cell cycle --- the division of cells to copy themselves. Cyclin D1 is the product of ccnd1 gene and plays an important role in regulation of cell cycle transition from G1 phase to S phase. The cell cycles of...
The prophage of bacteriophage P1 is a unit copy plasmid, stable in Escherichia coli during cell division due to its partition system. The active P1 partition system consists of two genes, parA and parB, and a cis-site, parS. ParS contains all of...
Human reproductive technology; Fertilization in vitro, Human
The purpose of this study was to evaluate the outcome of Intracytoplasmic Sperm Injection (ICSI) in patients with previous unexplained fertilization failure (≤20%) after conventional in vitro fertilization (IVF) in our program and to compare them...
Considering the pleiotropic manifestations of the rare, inherited, bone marrow failure disease, Fanconi Anemia, afflicted patients must be evaluated and monitored by specialty physicians (such as dermatologists, opthamologists, gastroenterologists,...
DNA -- Analysis; Nucleotide sequence; Cancer genes
The first methods for sequencing DNA were developed in the mid-1970’s (Strausberg et al. 2008). The sequencing efforts were labor-intensive, slow, and costly (Metzker, 2005). As a result, researchers could sequence only a few base pairs per...
Our lab has recently observed a triphasic hypertonicity induced current in stage IV-VI Xenopus laevis oocytes. This current is a calcium-dependant chloride current which is similar to that observed by (Hartzell, 1996). Hartzell, 1996) found that...
The tick has ability to transmit a greater variety of infectious agents to humans and other animal species than any other blood-feeding arthropod. Feeding over a period of days induces specific host hemostatic, inflammatory, and immune responses....
