In human hypertrophy and heart failure, death often occurs following an arrhythmia. Researchers are still looking for the underlying causes of these arrhythmias. It has been determined that ion channels control cardiac rhythm, and that...
AMP-dependent kinase (AMPK) is a primary energy sensor that controls energy use and production during metabolic cellular stress, such as hypoxia and nutrient deprivation. AMPK activation results in inhibition of anabolic processes and promotion...
Over fifty years after its introduction into clinical practice, succinylcholine is still the only depolarizing neuromuscular blocking agent used in this country today. It is highly favored in the clinical practice of anesthesia because of its rapid...
The ability of cells to migrate is important for development, neurite formation,
immune function, and other processes necessary for the life of an organism. However,
the gaining of an inappropriate migratory function, as well as, uncontrolled...
Transforming growth factor-alpha (TGFa), a member of the endothelial growth
factor (EGF) family of mitogens, was previously thought to exist solely in neoplastic
cells and the quickly dividing cells of a developing fetus. Since then, TGFa...
Animal models of Huntington's disease (HD) that utilize 3-nitropropionic acid (3-NPA) in the initiation of oxidative stress
and accelerated brain-aging have been extensively studied. When administered to rodents, 3-NPA irreversibly...
