The mouse frizzy (fr) mutation arose on a genetically mixed background and was first described by G.D. Snell of The Jackson Laboratory in 1951. Mice carrying this recessive mutation have curly vibrissae which can be observed as early as one to two...
Recent physiological investigations examining the cardiac calcium handling abilities of tuna and rainbow trout suggest increased reliance on sarcoplasmic reticulum calcium contribution for heart contractility that is both temperature and frequency...
The recessive male sterility and histoincompatibility mutation (mshi) in the mouse generates pleiotropic effects on graft transplantation and male reproduction. Previous analysis of backcross mice using a large set of microsatellite markers has...
RNA editing is a mechanism which is used to increase the number of possible protein products from a specific gene. The catalytic enzymes for RNA editing are known to be present in a wide variety of organisms, including many different insects. It...
The discovery of antibiotics was one of the greatest discoveries of the 21st 20th century (Van Kraaig, 1999 and Livermore, 2004). The current need for new antibiotics to fight bacterial pathogens that have become resistant is growing every day. ...
The frizzy (fr) mutation in Mus musculus affects hair structure and formation. Early studies demonstrated that the gene responsible for frizzy assorts to mouse Chromosome 7 along with pink-eyed dilution (p), chinchilla (cch), and shaker-1 (sh-1). ...
The mouse frizzy (fr) mutation is a Mendelian recessive trait that affects hair structure and formation in mice. The mutation arose in a mouse of mixed origin at the Jackson Lab (Bar Harbor, ME) in 1951. Frizzy is known to be linked to other genes...
Cell Migration is an integral part of normal biological development and biological processes, but also plays an important role in pathogenic processes including the progression of cancer towards metastasis. The mechanisms that regulate cell...
The tick has ability to transmit a greater variety of infectious agents to humans and other animal species than any other blood-feeding arthropod. Feeding over a period of days induces specific host hemostatic, inflammatory, and immune responses....
Abnormalities in the synaptic concentration of serotonin are often linked to clinical and psychiatric disorders. This concentration of serotonin is regulated, by serotonergic neurons, through a cycle of serotonin synthesis and vesicular packaging,...
Frizzy (fr) is a spontaneous recessive mutation in mice characterized by curly vibrissae, a disheveled coat and short hair (Snell 1951). Previous linkage analysis located the mutant fr allele on Mus musculus Chromosome 7 (Falconer and Snell 1952)....
Comfrey is an herb traditionally used for bone healing. It is also sold as a dietary supplement to promote respiratory health. Comfrey has been banned in Canada and Germany because of its link to liver damage or failure, but remains legal in the...
Receptor-mediated endocytosis as a route of gene delivery shows promise as it is a natural cellular process and allows targeting of ligands to specific cells. A carrier system consisting of two important components: a targetable ligand,...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
The ability of cells to migrate is important for development, neurite formation,
immune function, and other processes necessary for the life of an organism. However,
the gaining of an inappropriate migratory function, as well as, uncontrolled...
Parental behavior in animals; Rats -- Physiology; Animal mutation
Rats that are hypotrichotic (lacking normal hair) due to the autosomal recessive
shorn (shn) mutation showed a low survival rate in brother by sister matings in a breeding
colony of SU/Csu rats. The majority of rats died before weaning. Subsequent...
Depression is characterized by a mood and behavior, that can affect the ability of
a person to perform daily activities and interact with others. Depression is an illness that
can be caused by biochemical and environmental changes. Chemical...
The ability of embryonic stem cells to give rise to all cells comprising the three germ layers – endoderm, mesoderm and ectoderm – highlights a powerful in vivo system for the study of early embryonic development. Human embryonic stem cell...
The RNA molecule is responsible for providing information to the cell to assemble proteins specified by the DNA. A specific type of RNA editing can convert individual adenosines into inosine by an enzyme called adenosine deaminase acting on RNA...
Myogenesis is an important process that occurs during the developmental stages of an embryo. Stem cells learn of their fate during this course if they will become muscle cells and from there, differentiation within those muscle cells will take...
