This study looks at the Criminal DNA Database system and the submission requirements. DNA testing results have become a relevant and reliable source of evidence in criminal proceedings since 1988. Law enforcement uses a few different types of...
A-to-I RNA editing is an enzymatic reaction commonly found in the nervous system of various organisms. The mechanism behind this post-transcriptional modification is the hydrolytic deamination of Adenosine to Inosine by a family of enzymes known as...
DNA -- Analysis; Nucleotide sequence; Cancer genes
The first methods for sequencing DNA were developed in the mid-1970’s (Strausberg et al. 2008). The sequencing efforts were labor-intensive, slow, and costly (Metzker, 2005). As a result, researchers could sequence only a few base pairs per...
RNA editing is a mechanism which is used to increase the number of possible protein products from a specific gene. The catalytic enzymes for RNA editing are known to be present in a wide variety of organisms, including many different insects. It...
Receptor-mediated endocytosis as a route of gene delivery shows promise as it is a natural cellular process and allows targeting of ligands to specific cells. A carrier system consisting of two important components: a targetable ligand,...
The tick has ability to transmit a greater variety of infectious agents to humans and other animal species than any other blood-feeding arthropod. Feeding over a period of days induces specific host hemostatic, inflammatory, and immune responses....
Investigation of X-linked histocompatibility may offer an opportunity to find CD and HD minor H haplotype components which are widely separated on the X chromosome. The presence of the HX antigen is detected by placing parental strain grafts onto...
The RNA molecule is responsible for providing information to the cell to assemble proteins specified by the DNA. A specific type of RNA editing can convert individual adenosines into inosine by an enzyme called adenosine deaminase acting on RNA...
Tick-borne diseases have become a principal public health concern in the United States due to the tremendous increase in human contact with deer. This concern has been reflected in Connecticut as well in recent years. With changing demographic...
The pairing and recombination of homologous regions of the X and Y chromosomes, in an area known as the pseudoautosomal region (PAR), has been a phenomenon of interest since its discovery in 1934. Its presence seems to be limited to eutherian...
During the last decade, new technologies created a deluge of potential drug targets. Sifting through thousands of potential drug targets is a major industry bottleneck. Pharmaceutical companies can save billions of dollars by identifying most...
The frizzy (fr) mutation in Mus musculus affects hair structure and formation. Early studies demonstrated that the gene responsible for frizzy assorts to mouse Chromosome 7 along with pink-eyed dilution (p), chinchilla (cch), and shaker-1 (sh-1). ...
The intent of this research project was to purify the Shigella flexneri virulence plasmid without the use of ultra-centrifugation. The ultra-centrifugation is the most commonly used technique; however the PFGE has proven to isolate the plasmid...
The prophage of bacteriophage P1 is a unit copy plasmid, stable in Escherichia coli during cell division due to its partition system. The active P1 partition system consists of two genes, parA and parB, and a cis-site, parS. ParS contains all of...
Acetaminophen is extensively used as an analgesic and antipyretic agent, but at high doses it causes liver damage. The major metabolic pathways of acetaminophen are glucuronidation and sulfation. In addition to these pathways, acetaminophen...
Cyclin D1 is the major regulator of cell cycle --- the division of cells to copy themselves. Cyclin D1 is the product of ccnd1 gene and plays an important role in regulation of cell cycle transition from G1 phase to S phase. The cell cycles of...
Discovering RNA editing sites in model organisms provides an insight into their adaptations in addition to finding potential sites for gene expression regulation. In this study, we focused on the grin1b gene of Zebrafish due to its important...
