Acetaminophen is extensively used as an analgesic and antipyretic agent, but at high doses it causes liver damage. The major metabolic pathways of acetaminophen are glucuronidation and sulfation. In addition to these pathways, acetaminophen...
Considering the pleiotropic manifestations of the rare, inherited, bone marrow failure disease, Fanconi Anemia, afflicted patients must be evaluated and monitored by specialty physicians (such as dermatologists, opthamologists, gastroenterologists,...
The RNA molecule is responsible for providing information to the cell to assemble proteins specified by the DNA. A specific type of RNA editing can convert individual adenosines into inosine by an enzyme called adenosine deaminase acting on RNA...
Birth weight, Low; Premature infants--Physiology; Oxygen therapy for premature infants--Complications
Supplemental oxygen is one of the most prescribed interventions in the newborn intensive care unit (NICU). Hyperoxia is toxic to the lung tissue of preterm newborns particularly the very low birth weight infant and it has been implicated in the...
The ability of embryonic stem cells to give rise to all cells comprising the three germ layers – endoderm, mesoderm and ectoderm – highlights a powerful in vivo system for the study of early embryonic development. Human embryonic stem cell...
Cell Migration is an integral part of normal biological development and biological processes, but also plays an important role in pathogenic processes including the progression of cancer towards metastasis. The mechanisms that regulate cell...
The ability of cells to migrate is important for development, neurite formation,
immune function, and other processes necessary for the life of an organism. However,
the gaining of an inappropriate migratory function, as well as, uncontrolled...
Cell migration is an essential part of many processes including embryonic development, wound healing, and unwanted processes like metastasis. Further study of cell migration is needed to help understand these processes. A cell model system (F9...
AMP-dependent kinase (AMPK) is a primary energy sensor that controls energy use and production during metabolic cellular stress, such as hypoxia and nutrient deprivation. AMPK activation results in inhibition of anabolic processes and promotion...
Repeated exposure to addictive drugs causes unmistakable changes to occur on both a neuronal and a behavioral level. Certain circuits in the brain of an addict are forced to change and adapt to an environment of drug-induced chemical imbalance....
Cyclin D1 is the major regulator of cell cycle --- the division of cells to copy themselves. Cyclin D1 is the product of ccnd1 gene and plays an important role in regulation of cell cycle transition from G1 phase to S phase. The cell cycles of...
Transforming growth factor-alpha (TGFa), a member of the endothelial growth
factor (EGF) family of mitogens, was previously thought to exist solely in neoplastic
cells and the quickly dividing cells of a developing fetus. Since then, TGFa...
Our lab has recently observed a triphasic hypertonicity induced current in stage IV-VI Xenopus laevis oocytes. This current is a calcium-dependant chloride current which is similar to that observed by (Hartzell, 1996). Hartzell, 1996) found that...
The prophage of bacteriophage P1 is a unit copy plasmid, stable in Escherichia coli during cell division due to its partition system. The active P1 partition system consists of two genes, parA and parB, and a cis-site, parS. ParS contains all of...
Minor histocompatibility (H) antigens are typically identified as barriers to transplantation in graft exchange experiments between major histocompatibility complex (MHC)-matched hosts (Bailey 1975; Snell and Bunker 1960). This approach has allowed...
Surface Fitting is useful to researchers in fields from engineering to medicine. The expertise of mathematicians is needed to help with the analysis of data to help the experts in those fields draw appropriate conclusions. The research that this...
The male sterility and histoincompatibility mutant, mshi, results from a recessive mutation that arose spontaneously in the BALB/cBy inbred mouse strain. Using a 402-member BALB/cBy-mshi/mshi (BALB/cBy-mshi C57BL/6J) F1 backcross panel, the...
Mobile communication systems -- United States; Wireless communication systems -- United States; Communication in education -- United States
The purpose of this Capstone Project is to research and provide a solution on how mobile technology can be used as a communication tool between a faculty member and his or her students. The solution will be to allow faculty members the ability to...
The male sterility and histoincompatibility mutation (mshi) is an autosomal recessive mutation that produces apparently pleiotropic effects in mice. Mice homozygous for mshi manifest two distinct phenotypes. In both male and female mice, the...
Myogenesis is an important process that occurs during the developmental stages of an embryo. Stem cells learn of their fate during this course if they will become muscle cells and from there, differentiation within those muscle cells will take...
