"Submitted in Partial Fulfillment of the Requirement for the Degree of Master of Arts in Biomolecular Science."; Thesis advisor: Michael Davis.; M.A.,Central Connecticut State University,,2012.; Includes bibliographical references (leaves 42-45).
"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts in Biomolecular Sciences."; Thesis advisor: Cheryl Watson.; M.A.,Central Connecticut State University,,2012.; Includes bibliographical references (leave 42).
A-to-I RNA editing is an enzymatic reaction commonly found in the nervous system of various organisms. The mechanism behind this post-transcriptional modification is the hydrolytic deamination of Adenosine to Inosine by a family of enzymes known as...
Abnormalities in the synaptic concentration of serotonin are often linked to clinical and psychiatric disorders. This concentration of serotonin is regulated, by serotonergic neurons, through a cycle of serotonin synthesis and vesicular packaging,...
Ahearn et al. (J. Heredity 93:210-213) have previously shown that the rat fuzzy and Charles River "hairless" mutations are defects in the same gene on rat Chromosome 1, and are likely orthologues of mouse frizzy (abbreviated fr) on mouse Chromosome...
Cell migration is an essential part of many processes including embryonic development, wound healing, and unwanted processes like metastasis. Further study of cell migration is needed to help understand these processes. A cell model system (F9...
Cell Migration is an integral part of normal biological development and biological processes, but also plays an important role in pathogenic processes including the progression of cancer towards metastasis. The mechanisms that regulate cell...
Comfrey is an herb traditionally used for bone healing. It is also sold as a dietary supplement to promote respiratory health. Comfrey has been banned in Canada and Germany because of its link to liver damage or failure, but remains legal in the...
Cyclin D1 is the major regulator of cell cycle --- the division of cells to copy themselves. Cyclin D1 is the product of ccnd1 gene and plays an important role in regulation of cell cycle transition from G1 phase to S phase. The cell cycles of...
Depression is characterized by a mood and behavior, that can affect the ability of
a person to perform daily activities and interact with others. Depression is an illness that
can be caused by biochemical and environmental changes. Chemical...
Discovering RNA editing sites in model organisms provides an insight into their adaptations in addition to finding potential sites for gene expression regulation. In this study, we focused on the grin1b gene of Zebrafish due to its important...
During the development of potential protein or antibody therapeutics in a pharmaceutical environment, the use of animal models as test subjects is a necessary requirement. The dosing of mice, rats, and primates is essential to drug development...
Frizzy (fr) is a spontaneous recessive mutation in mice characterized by curly vibrissae, a disheveled coat and short hair (Snell 1951). Previous linkage analysis located the mutant fr allele on Mus musculus Chromosome 7 (Falconer and Snell 1952)....
Myogenesis is an important process that occurs during the developmental stages of an embryo. Stem cells learn of their fate during this course if they will become muscle cells and from there, differentiation within those muscle cells will take...
Parental behavior in animals; Rats -- Physiology; Animal mutation
Rats that are hypotrichotic (lacking normal hair) due to the autosomal recessive
shorn (shn) mutation showed a low survival rate in brother by sister matings in a breeding
colony of SU/Csu rats. The majority of rats died before weaning. Subsequent...
Recent physiological investigations examining the cardiac calcium handling abilities of tuna and rainbow trout suggest increased reliance on sarcoplasmic reticulum calcium contribution for heart contractility that is both temperature and frequency...
Receptor-mediated endocytosis as a route of gene delivery shows promise as it is a natural cellular process and allows targeting of ligands to specific cells. A carrier system consisting of two important components: a targetable ligand,...
RNA editing is a mechanism which is used to increase the number of possible protein products from a specific gene. The catalytic enzymes for RNA editing are known to be present in a wide variety of organisms, including many different insects. It...
The ability of cells to migrate is important for development, neurite formation,
immune function, and other processes necessary for the life of an organism. However,
the gaining of an inappropriate migratory function, as well as, uncontrolled...
The ability of embryonic stem cells to give rise to all cells comprising the three germ layers – endoderm, mesoderm and ectoderm – highlights a powerful in vivo system for the study of early embryonic development. Human embryonic stem cell...
